Self-consistent Treatment of Copolymers with Arbitrary Sequences

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dc.creatorKuznetsov, Yu. A.
dc.creatorTimoshenko, E. G.
dc.date2001-04-25
dc.date.accessioned2026-07-25T14:21:58Z
dc.descriptionUsing the Gaussian Ansatz for the monomer-monomer correlation functions we derive a set of the self-consistent equations for determination of the conformational state in the bead-and-spring copolymer model. The latter is based on the Edwards type effective free energy functional with arbitrary two-body interaction matrix. The rate of conformational changes in kinetics may be expressed via the instantaneous gradients of the variational free energy functional in the space of the averaged dynamical variables. We study the equilibrium and kinetics for some periodic and random aperiodic amphiphilic sequences in infinitely diluted solution. Typical equilibrium phase diagrams are elucidated and the conformational structure of different states is discussed. The kinetics of compaction of an amphiphilic copolymer to the globular state proceeds through formation of locally frustrated non-equilibrium structures. This leads to a rather complicated multistep kinetic process. We observe that even a small modification in the primary sequence of a copolymer may significantly change its kinetic folding properties.
dc.description16 pages, 25 PS figures
dc.identifierhttps://arxiv.org/abs/cond-mat/0104495
dc.identifierhttp://arxiv.org/abs/cond-mat/0104495
dc.identifierIl Nuovo Cimento. Vol. 20D, No 12bis, pp. 2265-2288 (1998)
dc.identifier.urihttps://dspace.dare.co.zw/handle/123456789/25084
dc.subjectSoft Condensed Matter
dc.subjectDisordered Systems and Neural Networks
dc.subjectMesoscale and Nanoscale Physics
dc.subjectQuantitative Biology
dc.titleSelf-consistent Treatment of Copolymers with Arbitrary Sequences
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